Defending champion Novak Djokovic reached the third round of the US Open on Wednesday as Laslo Djere retired in the third set, but said he’ll have to do better to win a fifth title on the hard courts of New York.

Djokovic was up 6-4, 6-4, 2-0 when Djere pulled the plug on a gritty encounter that saw both men summon the physio to Arthur Ashe Stadium.

“It’s not what we want to see,” Djokovic said. “He’s such a good player in these conditions and the second set should have been his, he was 4-2 up.

“I don’t know if (my) winning the second set probably put more burden on him.”

Djokovic notched his 90th US Open match victory, becoming the first man to win 90 at all four Grand Slams.

But it was a battle until the minute Djere called it quits

Djokovic grabbed the first break of the match to take the first set 6-4 after a tense hour then sought treatment for trouble on his right side.

Djere, the only player to take a set off Djokovic at last year’s US Open, gained the first break of the second set and with a 4-2 lead had two more break points that he couldn’t convert.

But Djokovic won the next six games, Djere receiving treatment on his abdomen before Djokovic closed out the second.

“Overall it was a big fight — over two hours for two sets,” Djokovic said.

“I served awful. So playing without the serve, you have to grind, you have to run. I had to rely on my baseline game.”

The Serbian superstar, coming off an emotional Paris Olympics triumph, next faces Australian Alexei Popyrin, who he beat at the Australian Open and Wimbledon this year.

Women’s defending champion Coco Gauff overcame her own struggles on serve to beat 37-year-old Tatjana Maria 6-4, 6-0.

It was an uneven performance from 20-year-old Gauff, who has endured an erratic season since capturing her maiden major in New York.

She put just 44 percent of her first serves in play and had nine double faults, but the 99th-ranked Maria couldn’t capitalize and Gauff won the last seven games to seal the win.

“I think I played well overall,” Gauff said. “I think if I could have served better that first set would have been a lot easier.”

Djokovic and Gauff missed the worst conditions of a steamy day that saw tournament organizers invoke the extreme weather rule allowing mid-match breaks.